Flow cytometry of ovarian neoplasms.

摘要: Epithelial carcinomas are the most common malignant tumors of ovary and cause death from genital malignancies in women (Ball et al. 1990). Although advances therapy have resulted prolonged disease-free survivals, these intensive treatments associated with substantial side-effects majority advanced stage epithelial carcinoma eventually die their tumor despite therapy. These factors a search for features that would permit greater prognostic accuracy tailoring treatment regimens to biologic behavior an individual patient. The development method DNA analysis on paraffin-embedded tissue by Hedley co-workers (Hedley 1983, 1985; 1989) has prompted numerous investigations significance content cell cycle as possibly more objective reproducible indicators behavior. studies examined relation flow cytometric known survival surface carcinomas; smaller number addressed issues ovarian neoplasms other types. This article will briefly summarize technical aspects cytometry, concentrating difficulties may interfere analysis, then review detail ploidy data clinical histologic each type.