Chapter 1 The role of volume regulation in intestinal transport: Insights from villus cells in suspension
作者： R.John MacLeod
DOI: 10.1016/S1063-5823(00)50003-9
关键词: Volume (thermodynamics) 、 Biochemistry 、 Absorption (pharmacology) 、 Swelling 、 Chemistry 、 Biophysics 、 Second messenger system 、 Small intestine 、 Suspension (chemistry) 、 Signal transduction 、 Enterocyte
摘要: Publisher Summary This chapter discusses the role of volume regulation in intestinal transport from insights villus cells suspension. Absorptive small intestine swell when they absorb Na + co- transported solutes, such as D -glucose and L -alanine. cell swelling is followed by a recovery or regulatory decrease (RVD), which because activation K Cl – channels. The differences signaling RVD after three different experimental maneuvers are summarized chapter. A putative sensor activated extent increase. occurring caused -solute absorption, however, requires several factors. signal transduction responsible for channel differs two models swelling. difference these suggests that additional second messengers generated to regulate occurs an intact cell. Therefore, mechanism increase both determinants enterocyte regulation.
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