Membrane mechanisms and intracellular signalling in cell volume regulation.

作者: Else K. Hoffmann , Philip B. Dunham

DOI: 10.1016/S0074-7696(08)62498-5

关键词:

摘要: Recent work on selected aspects of the cellular and molecular physiology cell volume regulation is reviewed. First, physiological significance discussed. Membrane transporters involved in are reviewed, including volume-sensitive K + CI − , channels, Na 2CI cotransporters, H HCO 3 exchangers. The role amino acids, particularly taurine, as osmolytes Possible mechanisms by which cells sense their volumes, along with sensors these signals, signals mechanical changes membrane macromolecular crowding. Sensors include stretch-activated cytoskeleton, specific or cytoplasmic enzymes. Mechanisms for transduction signal from to These Ca 2+ -calmodulin system, phospholipases, polyphosphoinositide metabolism, eicosanoid protein kinases phosphatases. A detailed model presented swelling-initiated pathway Ehrlich ascites tumor cells. Finally, coordinated control volume-regulatory transport processes expression organic osmolyte long-term adaptation osmotic stress reviewed briefly.

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