Age-Dependent vasopressinergic modulation of Noc/oFQ-induced impairment of NMDA cerebrovasodilation after brain injury.
作者： William M. Armstead
DOI: 10.1089/089771501750291855
关键词: Vasopressin 、 Neuropeptide 、 Vasopressin Antagonists 、 Nociceptin receptor 、 Internal medicine 、 Cerebral circulation 、 Peptide hormone 、 NMDA receptor 、 Pathophysiology 、 Endocrinology 、 Medicine
摘要: This study was designed to characterize the role of vasopressin in nociceptin/orphanin FQ (NOC/oFQ)-induced impairment NMDA cerebrovasodilation after fluid percussion brain injury (FPI) as a function age newborn (1-5 days old) and juvenile (3-4 weeks pigs equipped with closed cranial window. Previous studies have observed that NOC/oFQ is released into CSF contributes impaired induced pial artery dilation following FPI greater extent versus pigs. Topical (40 pg/mL), concentration approximating newborn, increased from 69 ± 3 102 8 pg/mol under non-FPI conditions. elevated within 60 min (70 444 51 but release attenuated by MEAVP, antagonist, (71 146 11 pg/mL). were not greatly MEAVP correspondingly did attenuate rel...
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