Differential role of PTK, ERK and p38 MAPK in superoxide impairment of NMDA cerebrovasodilation.
作者： Shaji Philip , William M. Armstead
DOI: 10.1016/S0006-8993(03)02879-8
关键词: Vasodilation 、 Glutamate receptor 、 Superoxide 、 MAPK/ERK pathway 、 Vasoconstriction 、 p38 mitogen-activated protein kinases 、 Protein kinase A 、 Internal medicine 、 NMDA receptor 、 Biology 、 Endocrinology
摘要: Abstract Previous studies in piglets have shown that the generation of oxygen free radicals (O−2) following traumatic brain injury and hypoxia/ischemia contribute to reversal N-methyl- d -aspartate (NMDA)-induced pial artery dilation vasoconstriction. This study determined contribution protein tyrosine kinase (PTK) mitogen-activated (MAPK) activation impairment NMDA cerebrovasodilation by O−2 equipped with a closed window. Exposure cerebral cortex xanthine oxidase generating system (OX) reversed (10−8, 10−6 M) vasoconstriction but such was partially prevented PTK inhibitor, genistein, MAPK (ERK isoform) U0126, (p38 SB203580 (9±1 15±1 vs. −1±1 5±1 9±1% for sham control, OX presence respectively). However, p38 SB203580, dilator significantly less than ERK U0126. Similar results were obtained glutamate. These data show contributes dilation. Furthermore, these indicate differential role brain.
elsevier.com
sci-hub.se 参考文章(40)
William M. Armstead, Age-Dependent vasopressinergic modulation of Noc/oFQ-induced impairment of NMDA cerebrovasodilation after brain injury. Journal of Neurotrauma. ,vol. 18, pp. 615- 623 ,(2001) , 10.1089/089771501750291855
E. P. Wei, C. W. Christman, H. A. Kontos, J. T. Povlishock, Effects of oxygen radicals on cerebral arterioles American Journal of Physiology-heart and Circulatory Physiology. ,vol. 248, ,(1985) , 10.1152/AJPHEART.1985.248.2.H157
Miriam Kulkarni, William M. Armstead, Superoxide Generation Links Nociceptin/Orphanin FQ (NOC/oFQ) Release to Impaired N-Methyl-d-Aspartate Cerebrovasodilation After Brain Injury Stroke. ,vol. 31, pp. 1990- 1996 ,(2000) , 10.1161/01.STR.31.8.1990
Roland Veltkamp, Ferenc Domoki, Ferenc Bari, Thomas M. Louis, David W. Busija, Inhibitors of protein synthesis preserve the N-methyl-D-aspartate-induced cerebral arteriolar dilation after ischemia in piglets. Stroke. ,vol. 30, pp. 148- 152 ,(1999) , 10.1161/01.STR.30.1.148
JOSEPH S. BECKMAN, Peroxynitrite versus Hydroxyl Radical: The Role of Nitric Oxide in Superoxide-Dependent Cerebral Injurya Annals of the New York Academy of Sciences. ,vol. 738, pp. 69- 75 ,(2006) , 10.1111/J.1749-6632.1994.TB21791.X
William M Armstead, NOC/oFQ contributes to hypoxic–ischemic impairment of N-methyl-d-aspartate-induced cerebral vasodilation Brain Research. ,vol. 868, pp. 48- 55 ,(2000) , 10.1016/S0006-8993(00)02262-9
F M Faraci, K R Breese, Nitric oxide mediates vasodilatation in response to activation of N-methyl-D-aspartate receptors in brain. Circulation Research. ,vol. 72, pp. 476- 480 ,(1993) , 10.1161/01.RES.72.2.476
Azad Bonni, Anne Brunet, Anne E West, Sandeep Robert Datta, Mari A Takasu, Michael E Greenberg, Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms Science. ,vol. 286, pp. 1358- 1362 ,(1999) , 10.1126/SCIENCE.286.5443.1358
Miriam Kulkarni, William M. Armstead, Relationship between NOC/oFQ, dynorphin, and COX-2 activation in impaired NMDA cerebrovasodilation after brain injury. Journal of Neurotrauma. ,vol. 19, pp. 965- 973 ,(2002) , 10.1089/089771502320317113
F.C. Barone, E.A. Irving, A.M. Ray, J.C. Lee, S. Kassis, S. Kumar, A.M. Badger, J.J. Legos, J.A. Erhardt, E.H. Ohlstein, A.J. Hunter, D.C. Harrison, K. Philpott, B.R. Smith, J.L. Adams, A.A. Parsons, Inhibition of p38 mitogen-activated protein kinase provides neuroprotection in cerebral focal ischemia. Medicinal Research Reviews. ,vol. 21, pp. 129- 145 ,(2001) , 10.1002/1098-1128(200103)21:2<129::AID-MED1003>3.0.CO;2-H