Genitourinary malformations in neonates conceived by human assisted reproductive technologies Malformações do aparelho geniturinário em recém-nascidos concebidos por técnicas de reprodução humana assistida

作者: Arnaldo Augusto , Franco de Siqueira , Marcia de Freitas , Conceição Aparecida de Mattos Segre

DOI:

关键词: PopulationReproductionStatistical significanceIntracytoplasmic sperm injectionIn vitro fertilisationMedicineRetrospective cohort studyGenitourinary systemGynecology

摘要: Objective: To identify genitourinary malformations among children conceived by assisted reproductive techniques in a population of pregnant women seen at tertiary hospital the city Sao Paulo, Brazil. Methods: A descriptive and retrospective study with data collected from 238 who underwent reproduction techniques, including classic vitro fertilization intracytoplasmic sperm injection, gave birth to 322 Hospital Israelita Albert Einstein. results: The mean maternal age for was 34 years injection 34.8 years. There an increase malformed older age, but no statistical significance. Thirty-four newborns were found (10.6%) 10 (29.4% children) presented malformations. conclusions: Several following human there tendency malformation as increased.

参考文章(18)
J. Zádori, Z. Kozinszky, H. Orvos, M. Katona, S. G. Kaáli, A. Pál, THE INCIDENCE OF MAJOR BIRTH DEFECTS FOLLOWING IN VITRO FERTILIZATION Journal of Assisted Reproduction and Genetics. ,vol. 20, pp. 131- 132 ,(2003) , 10.1023/A:1022682908307
Bengt Kallen, Orvar Finnstrom, K.G. Nygren, Petra Otterblad Olausson, Ulla-Britt Wennerholm, In vitro fertilisation in Sweden : obstetric characteristics, maternal morbidity and mortality British Journal of Obstetrics and Gynaecology. ,vol. 112, pp. 1529- 1535 ,(2005) , 10.1111/J.1471-0528.2005.00745.X
Bengt Källén, Orvar Finnström, Karl-Gösta Nygren, Petra Otterblad Olausson, In vitro fertilization (IVF) in Sweden: infant outcome after different IVF fertilization methods. Fertility and Sterility. ,vol. 84, pp. 611- 617 ,(2005) , 10.1016/J.FERTNSTERT.2005.02.038
Monica Rittler, Joaquin E. Paz, Eduardo E. Castilla, VACTERL association, epidemiologic definition and delineation American Journal of Medical Genetics. ,vol. 63, pp. 529- 536 ,(1996) , 10.1002/(SICI)1096-8628(19960628)63:4<529::AID-AJMG4>3.0.CO;2-J
Béatrice Blondel, Michael D. Kogan, Greg R. Alexander, Nirupa Dattani, Michael S. Kramer, Alison Macfarlane, Shi Wu Wen, The Impact of the Increasing Number of Multiple Births on the Rates of Preterm Birth and Low Birthweight: An International Study American Journal of Public Health. ,vol. 92, pp. 1323- 1330 ,(2002) , 10.2105/AJPH.92.8.1323
Michael Ludwig, Alexander Katalinic, German ICSI Follow-up Study Group, Malformation rate in fetuses and children conceived after ICSI: results of a prospective cohort study Reproductive Biomedicine Online. ,vol. 5, pp. 171- 178 ,(2002) , 10.1016/S1472-6483(10)61621-5
Michèle Hansen, Jennifer J. Kurinczuk, Carol Bower, Sandra Webb, The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization. The New England Journal of Medicine. ,vol. 346, pp. 725- 730 ,(2002) , 10.1056/NEJMOA010035
Maryse Bonduelle, I Ponjaert, A Van Steirteghem, M‐P Derde, Paul Devroey, Inge Liebaers, Developmental outcome at 2 years of age for children born after ICSI compared with children born after IVF. Human Reproduction. ,vol. 18, pp. 342- 350 ,(2003) , 10.1093/HUMREP/DEG061
Michèle Hansen, Carol Bower, Elizabeth Milne, Nicholas de Klerk, Jennifer J.Kurinczuk, Assisted reproductive technologies and the risk of birth defects—a systematic review Human Reproduction. ,vol. 20, pp. 328- 338 ,(2005) , 10.1093/HUMREP/DEH593