Modulation of glycolysis and lipogenesis by novel PI3K selective molecule represses tumor angiogenesis and decreases colorectal cancer growth.
作者： Aashiq Hussain , Asif Khurshid Qazi , Nagaraju Mupparapu , Santosh Kumar Guru , Ashok Kumar
DOI: 10.1016/J.CANLET.2016.02.030
关键词: Downregulation and upregulation 、 Flux (metabolism) 、 Biology 、 Metastasis 、 Warburg effect 、 Biochemistry 、 Cancer research 、 Lipogenesis 、 Angiogenesis 、 Cancer 、 PI3K/AKT/mTOR pathway
摘要: Phosphatidylinositol 3-kinase (PI3K) pathway drives cancer progression through direct regulation of most oncogenic properties. Here, we report that PI3K signaling up-regulates cell proliferation, metastasis and angiogenesis modulation metabolism. These metabolic processes were disrupted, by a novel inhibitor, 3-Dihydro-2-(naphthalene-1-yl) quinazolin-4(1H)-one (DHNQ) in colon cells. DHNQ inhibited the Warburg effect lipid synthesis reducing gene expression glycolytic lipogenesis regulatory enzymes. This downregulation at level flux to repress migration invasion characteristics cancer. Furthermore, attenuation caused repression vitro/in vivo providing new insights regulated via alterations. Our results suggest multifaceted targeting metabolism their upstream may be an effective treatment approach.
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