Superoxide dismutase, glutathione peroxidase and catalase in developing rat brain.

摘要: The specific activities of Cu,Zn- and Mn-superoxide dismutases, glutathione peroxidase catalase, the enzymes considered to be specifically involved in defence cell against partially reduced forms oxygen, were determined as function postnatal age early (up 60 days) period rat brain development. assayed cytoplasmic fraction, crude mitochondrial fraction including peroxisomes, mitochondria. results show that temporal changes these cannot correlated with each other, thus indicating they do not concertedly parallel increasing activity aerobic metabolism during Specifically shows a gradual increase Cu,Zn-superoxide dismutase age, whereas is constant from birth. Furthermore more remarkable than Cu,Zn-enzyme. Higher catalase adult animals are detectable only subcellular containing because modest brain. These indicate independent regulation expression enzyme process differentiation point relative deficiency enzymic protection potentially toxic oxygen derivatives. This situation similar pattern already described heart mouse ascites-tumour cells, at variance much efficient present hepatocytes.