Ligands for L-Selectin: Homing, Inflammation, and Beyond
作者： Steven D. Rosen
DOI: 10.1146/ANNUREV.IMMUNOL.21.090501.080131
关键词: Homing (hematopoietic) 、 Inflammation 、 Cell biology 、 L-selectin 、 Cell adhesion 、 Effector 、 Leukocyte Trafficking 、 Immunology 、 Selectin 、 Biology 、 Lymphocyte homing receptor 、 Immunology and Allergy
摘要: Understanding the molecular basis of lymphocyte homing to lymphoid organs was originally a problem concern only immunologists. With discovery L-selectin and its ligands, interested scientists have expanded include glycobiologists, immunopathologists, cancer biologists, developmental biologists. Going beyond first discovered role in lymph nodes, system is implicated such diverse processes as inflammatory leukocyte trafficking both acute chronic settings, hematogenous metastasis carcinoma cells, effector mechanisms for demyelination axons, implantation early mammalian embryo. This review focuses on ligands that are found vascular endothelium, leukocytes, at various extravascular sites. The selectins their has validated long-predicted hypothesis carbohydrate-directed cell adhesion relevant eukaryotic systems. Emphasis will be given carbohydrate sulfation modifications which enable recognition by L-selectin. rapid "homing" labeled cells into nodes presumably had special affinity small lymphocytes endothelium postcapillary venules.
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