Modulation of protein tyrosine phosphorylation in rat insular cortex after conditioned taste aversion training.

摘要: Abstract Protein tyrosine phosphorylation is a major signal transduction pathway involved in cellular metabolism, growth, and differentiation. Recent data indicate that also plays role neuronal plasticity. We are using conditioned taste aversion, fast robust associative learning paradigm subserved among other brain areas by the insular cortex, to investigate molecular correlates of memory rat cortex. In rats learn associate novel (e.g., saccharin) with delayed poisoning LiCl injection). Here we report after aversion training, there rapid marked increase set proteins cortex but not areas. A protein so modulated, 180 kDa, abundant membrane fraction remains modulated for more than an hour training. Exposure alone results only small modulation aforementioned whereas administration malaise-inducing agent per se has no effect. To best our knowledge, this first demonstration behavioral experience.