Opening the door to innovation

作者: Janine Schuurman , Yvo F Graus , Aran F Labrijn , Sigrid R Ruuls , Paul WHI Parren

DOI: 10.4161/MABS.29004

关键词: Antibodies monoclonalDrug approvalMarketing buzzLeft and rightPublic relationsNanotechnologyBusinessAllianceBispecific antibodyOpen innovation

摘要: Open innovation is the new buzz, with initiatives popping up left and right. Here, we give a personal perspective on very successful, knowledge-driven initiated in an academia- industry alliance, which culminated technology platforms that enable generation of therapeutic antibodies novel properties. To start, provide general background open drug development field.

参考文章(61)
Paul Parren, Aran Frank Labrijn, Tom Vink, Jan van de Winkel, Stefan Loverix, Janine Schuurman, Ignace Lasters, Joost J. Neijssen, Methods for producing mixtures of antibodies ,(2010)
Open Innovation: The New Imperative for Creating and Profiting from Technology European Journal of Innovation Management. ,vol. 7, pp. 325- 326 ,(2004) , 10.1108/14601060410565074
Paul Parren, Willem Karel Bleeker, Frank Beurskens, Tom Vink, Jan van de Winkel, Janine Schuurman, Patrick van Berkel, Aran Frank Labrljn, Fusion or linked proteins with extended half life ,(2008)
J S van der Zee, R C Aalberse, P van Swieten, Serologic aspects of IgG4 antibodies. II: IgG4 antibodies form small, nonprecipitating immune complexes due to functional monovalency Journal of Immunology. ,vol. 137, pp. 3566- 3571 ,(1986)
Paul Parren, Ignace Laster, Aran Frank Labrijn, Jan van de Winkel, Stefan Loverix, Janine Schuurman, Antibody variants having modifications in the constant region ,(2009)
P. W. H. I. Parren, J. Wokke, S. Berrih-Aknin, D. R. Burton, M. H. De Baets, P. J. Van Breda Vriesman, Y. F. Graus, Human anti-nicotinic acetylcholine receptor recombinant Fab fragments isolated from thymus-derived phage display libraries from myasthenia gravis patients reflect predominant specificities in serum and block the action of pathogenic serum antibodies. Journal of Immunology. ,vol. 158, pp. 1919- 1929 ,(1997)
D J King, J R Adair, S Angal, D C Low, K A Proudfoot, J C Lloyd, M W Bodmer, G T Yarranton, Expression, purification and characterization of a mouse-human chimeric antibody and chimeric Fab' fragment. Biochemical Journal. ,vol. 281, pp. 317- 323 ,(1992) , 10.1042/BJ2810317
Paul Parren, Joyce I. Meesters, Ewald T. J. Van Den Bremer, Patrick Priem, Michael Gramer, Aran Frank Labrijn, Arnout Gerritsen, Werner L. Vos, Amitava Kundu, Janine Schuurman, Patrick van Berkel, Joost J. Neijssen, Muriel Van Kamper, Production of heterodimeric proteins ,(2012)
Paul Parren, Willem Karel Bleeker, Frank Beurskens, Tom Vink, Jan G.J. Van De Winkel, Janine Schuurman, Patrick Van Berkel, Recombinant monovalent antibodies and methods for production thereof ,(2006)
Monika Lessl, Stefanie Schoepe, Anette Sommer, Martin Schneider, Khusru Asadullah, Grants4Targets - an innovative approach to translate ideas from basic research into novel drugs. Drug Discovery Today. ,vol. 16, pp. 288- 292 ,(2011) , 10.1016/J.DRUDIS.2010.11.013