Predictive Value of Sequential Electroencephalogram (EEG) in Neonates With Seizures and Its Relation to Neurological Outcome

摘要: The aim of this study was to evaluate the relationship sequential neonatal electroencephalography (EEG) and neurological outcome in neonates with seizures identify polysomnographic features predictive outcome. Sequential EEGs recordings 58 that belonged 2 historical cohorts newborns from same intensive care unit who had follow-up at Neurodevelopment Clinic Hospital Sao Lucas, Pontificia Universidade Catolica do Rio Grande Sul (PUCRS) Porto Alegre, Brazil, were analyzed classified into 4 groups: normal-normal, abnormal-normal, abnormal-abnormal, normal-abnormal. In patients more than recordings, during period, first EEG compared following abnormal. A total pairs analyzed. Considering EEG, a statistically significant difference observed between result exam, if it abnormal, developmental delay (P = .030) postnatal death .030). Abnormal background activity also related neurodevelopment .041). sequences abnormal-abnormal normal-abnormal significantly correlated epilepsy ( P .015). associated .006) burst suppression pattern when present any .013) .034). abnormal patterns second increased risk for (relative [RR] 1.8; 95% confidence interval [CI] 1.03-3.0) (RR 2.20; CI 1.3-3.0). only electroencephalogram All (n 33) probable hypoxic ischemic encephalopathy abnormalities Postnatal diagnosed 24 infants (41.4%). Five (20.8%) presented West syndrome, 7 (29.2%) focal symptomatic epilepsy, 6 (25%) generalized (8.3%) early myoclonic encephalopathy, 1 (4.2%) infantile epileptic 3, syndrome undefined (12.5%). 5) some degree delay. conclusion, our findings suggest has value estimate outcomes delay, single recording. even determine ictal or organization sleep state.