Styrene-oxide N-terminal valine haemoglobin adducts in reinforced plastic workers: Possible influence of genetic polymorphism of drug-metabolising enzymes
作者： J.P. Teixeira , J. Gaspar , J. Roma-Torres , S. Silva , C. Costa
DOI: 10.1016/J.TOX.2007.04.019
关键词: Glutathione 、 Epoxide 、 Monooxygenase 、 Biochemistry 、 Valine 、 Epoxide hydrolase 、 Styrene 、 Styrene oxide 、 Cytochrome P450 、 Chemistry
摘要: Abstract Styrene is one of the most important organic chemicals used worldwide. In humans, styrene metabolism involves oxidation by cytochrome P450 monooxygenases (CYPs) to styrene-7,8-oxide, an epoxide thought be responsible for genotoxic effects exposure, and detoxification means hydrolase (mEH) glutathione S -transferases (GSTs). The objective this study was investigate if genetic polymorphisms metabolic enzymes modulate level urinary metabolites oxide adducts with N-terminal valine human globin (SO-Hb) in 75 workers occupationally exposed 77 unexposed controls. mean air concentration breathing zone (30.4 ppm) higher than threshold limit value 20 ppm recommended American Conference Governmental Industrial Hygienists (ACGIH), biological exposure index adopted ACGIH prior next shift (MA + PGA = 400 mg/g creatinine) exceeded, indicating that group recommended. A highly significant correlation observed between MA + PGA urine ( r = 0.85, P
core.ac.uk
le.ac.uk
elsevier.com
sci-hub.se 参考文章(23)
Pavel Vodička, Tatiana Tvrdik, Siv Osterman-Golkar, Ludmila Vodičková, Kateřina Peterková, Pavel Souček, Jana Šarmanová, Peter B Farmer, Fredrik Granath, Bo Lambert, Kari Hemminki, An evaluation of styrene genotoxicity using several biomarkers in a 3-year follow-up study of hand-lamination workers. Mutation Research-genetic Toxicology and Environmental Mutagenesis. ,vol. 445, pp. 205- 224 ,(1999) , 10.1016/S1383-5718(99)00127-8
Tamie Nakajima, Eivor Elovaara, Frank J. Gonzalez, Harry V. Gelboin, Hannu Raunio, Olavi Pelkonen, Harri Vainio, Toshifumi Aoyama, Styrene metabolism by cDNA-expressed human hepatic and pulmonary cytochromes P450. Chemical Research in Toxicology. ,vol. 7, pp. 891- 896 ,(1994) , 10.1021/TX00042A026
Susan Jenkins Sumner, Timothy R. Fennell, Review of the metabolic fate of styrene. Critical Reviews in Toxicology. ,vol. 24, ,(1994) , 10.3109/10408449409020138
Ronald T. H. van Welie, Rob G. J. M. van Dijck, Nico P. E. Vermeulen, Nico J. van Sittert, Mercapturic acids, protein adducts, and DNA adducts as biomarkers of electrophilic chemicals Critical Reviews in Toxicology. ,vol. 22, pp. 271- 306 ,(1992) , 10.3109/10408449209146310
Giuseppe De Palma, Paola Manini, Paola Mozzoni, Roberta Andreoli, Enrico Bergamaschi, Stefania Cavazzini, Innocente Franchini, Antonio Mutti, Polymorphism of Xenobiotic-Metabolizing Enzymes and Excretion of Styrene-Specific Mercapturic Acids Chemical Research in Toxicology. ,vol. 14, pp. 1393- 1400 ,(2001) , 10.1021/TX015505X
SM Rappaport, K Yeowell-O’Connell, Protein adducts as dosimeters of human exposure to styrene, styrene-7,8-oxide, and benzene. Toxicology Letters. ,vol. 108, pp. 117- 126 ,(1999) , 10.1016/S0378-4274(99)00080-6
S. Fustinoni, C. Colosio, A. Colombi, K. Yeowell-O'Connell, L. Lastrucci, S. M. Rappaport, Albumin and hemoglobin adducts as biomarkers of exposure to styrene in fiberglass-reinforced-plastics workers International Archives of Occupational and Environmental Health. ,vol. 71, pp. 35- 41 ,(1998) , 10.1007/S004200050247
Lucia Migliore, Alessio Naccarati, Fabio Coppedè, Enrico Bergamaschi, Giuseppe De Palma, Anu Voho, Paola Manini, Hilkka Järventaus, Antonio Mutti, Hannu Norppa, Ari Hirvonen, Cytogenetic biomarkers, urinary metabolites and metabolic gene polymorphisms in workers exposed to styrene. Pharmacogenetics and Genomics. ,vol. 16, pp. 87- 99 ,(2006) , 10.1097/01.FPC.0000182783.70006.44
Helena Kivist�, Kaija Pekari, Antero Aitio, Analysis and stability of phenylglyoxylic and mandelic acids in the urine of styrene-exposed people International Archives of Occupational and Environmental Health. ,vol. 64, pp. 399- 403 ,(1993) , 10.1007/BF00517945
P. Apostoli, F. Brugnone, L. Perbellini, V. Cocheo, M. L. Bellomo, R. Silvestri, Occupational styrene exposure: Environmental and biological monitoring American Journal of Industrial Medicine. ,vol. 4, pp. 741- 754 ,(1983) , 10.1002/AJIM.4700040607