Developmental and sex differences in cardiac tolerance to ischemia-reperfusion injury: the role of mitochondria 1
作者： B. Ostadal , Z. Drahota , J. Houstek , M. Milerova , I. Ostadalova
关键词: Ischemia 、 Mitochondrion 、 Medicine 、 Reperfusion injury 、 ATP synthase 、 Calcium 、 Mitochondrial permeability transition pore 、 Internal medicine 、 MPTP 、 Cyclophilin 、 Endocrinology
摘要: Age and sex play an essential role in the cardiac tolerance to ischemia-reperfusion injury: resistance significantly decreases during postnatal maturation female heart is more tolerant than male myocardium. It widely accepted that mitochondrial dysfunction, particularly permeability transition pore (MPTP) opening, plays a major determining extent of injury. We have observed MPTP sensitivity calcium load differs mitochondria isolated from neonatal adult myocardium, as well hearts. Neonatal are resistant both rate swelling induced by high concentration. Our data further suggest age- sex-dependent specificity not result different amounts ATP synthase cyclophilin D: hearts, similarly contain comparable its regulatory protein D. can speculate lower calcium-induced may be related higher ischemic
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