Light microscopic and ultrastructural observations of a metastasizing malignant epithelioid schwannoma

作者: Mariano M. Alvira , Thaddeus I. Mandybur , Max G. Menefee

DOI: 10.1002/1097-0142(197611)38:5<1977::AID-CNCR2820380519>3.0.CO;2-I

关键词: SchwannomaPathologyEpithelioid cellUltrastructureMembraneCellular differentiationBiologyVesicleGround substanceCell biologyBasal (phylogenetics)Cancer researchOncology

摘要: The light microscopy and ultrastructure of a malignant eipthelioid schwannoma are described. Characteristic cells resembling perineural elements with various degrees differentiation were observed. Primitive epithelioid contained scant ergastoplasm, few tubules filaments, but did have abundant free ribosomes Golgi membranes. Also noted junctional complexes focal fusion plasma membranes, basal laminae absent. Better differentiated completely limited by well-developed membrane had an abundance intracytoplasmic filaments multiple pinocytotic vesicles. intercellular ground substance was composed numerous fine collagen fibrils amorphous, basement membrane-like, electron-dense material. A striking ultrastructural similarity the tumor to those encountered in ethylnitrosourea-induced schwannomas rats noteworthy.

参考文章(9)
W. Wechsler, A. Koestner, J. A. Swenberg, Transplacental production with ethylnitrosourea of neoplasms of the nervous system in Sprague-Dawley rats. American Journal of Pathology. ,vol. 63, pp. 37- 56 ,(1971)
Thomas Pk, The connective tissue of peripheral nerve: an electron microscope study. Journal of Anatomy. ,vol. 97, pp. 35- 44 ,(1963)
JOHN D. WAGGENER, S. M. BUNN, JOHN BEGGS, The Diffusion of Ferritin Within the Peripheral Nerve Sheath: An Electron Microscopy Study Journal of Neuropathology and Experimental Neurology. ,vol. 24, pp. 430- 443 ,(1965) , 10.1097/00005072-196507000-00005
Edward J.H. Nathaniel, Daniel C. Pease, Regenerative changes in rat dorsal roots following wallerian degeneration Journal of Ultrastructure Research. ,vol. 9, pp. 533- 549 ,(1963) , 10.1016/S0022-5320(63)80083-0
Frank N. Low, The extracellular portion of the human blood‐air barrier and its relation to tissue space Anatomical Record-advances in Integrative Anatomy and Evolutionary Biology. ,vol. 139, pp. 105- 123 ,(1961) , 10.1002/AR.1091390203
Wechsler W, Swenberg Ja, Koestner A, The induction of tumors of the nervous system with intravenous methylnitrosourea. Laboratory Investigation. ,vol. 26, pp. 74- 85 ,(1972)
James C. Harkin, Richard Jay Reed, Tumors of the peripheral nervous system Armed Forces Institute of Pathology. ,(1969)