The lysosomal TRPML1 channel regulates triple negative breast cancer development by promoting mTORC1 and purinergic signaling pathways.
作者： Mengnan Xu , Shekoufeh Almasi , Yiming Yang , Chi Yan , Andra Mihaela Sterea
DOI: 10.1016/J.CECA.2019.02.010
关键词: Purinergic receptor 、 Purinergic signalling 、 Cancer research 、 Biology 、 Downregulation and upregulation 、 mTORC1 、 Signal transduction 、 Triple-negative breast cancer 、 Targeted drug delivery 、 Tumor microenvironment
摘要: … In this study, we report that TRPML1 … TRPML1 regulates TNBC development, at least partially, through controlling mTORC1 activity and the release of lysosomal ATP. Because TRPML1 …
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