The genetic contribution and relevance of knee cartilage defects: case-control and sib-pair studies.

摘要: OBJECTIVE: To describe the differences in knee cartilage defects between offspring of subjects with at least one parent a total replacement for severe primary osteoarthritis (OA) and controls; to estimate heritability sib-pairs. METHODS: Population based, case-control study 186 matched pairs (mean age 45 yrs, range 26-61) sib-pair 128 from 51 families (115 sib-pairs) within study. Knee defect scores (0-4) prevalence (a score > or = 2) were assessed patellar, tibial, femoral sites by processing images acquired using T1 weighted fat-saturated magnetic resonance imaging. Heritability was estimated SOLAR genetic analysis program. RESULTS: The surprisingly high (50% scored 2 any site). Compared controls, had higher tibiofemoral (4.39 vs 4.01, p 0.003; 41% 28%, 0.009), patellar (1.32 1.10, 0.031; 35% 26%, 0.075), whole (5.71 5.10, 0.002; 57% 42%, 0.007) compartments. These all became nonsignificant after adjustment pain radiographic OA. In component, prevalence, respectively, 38% (p 0.072) 47% 0.082) tibiofemoral, 52% 0.009) 78% 0.025) 43% 0.038) 68% estimates weaker compartments bone size, pain, CONCLUSION: are common, have component that is linked contribution may role pathogenesis