Supplemental Zinc Lowers Measures of Iron Status in Young Women with Low Iron Reserves

摘要: Zinc and iron compete during intestinal absorption, but postabsorptive interactions between these nutrients are less clear. Understanding is important to determine when supplementation with or zinc proposed. The effect of (22 mg Zn/d as gluconate) (100 Fe/d ferrous sulfate) for 6 wk on metabolism absorption was evaluated in young women low reserves. Young adult (ages 20-28 y), nonanemic stores (plasma ferritin< 20 microg/L), participated the 70-d study. were divided two groups (zinc-supplemented, n = 11; iron-supplemented, 12). supplements taken at bedtime. Iron biochemical indices measured d 1 56. Radioiron stable isotopes used measure from a test meal. In iron-supplemented group, blood hemoglobin, plasma ferritin percentage transferrin saturation increased (P < 0.01). did not change. zinc-supplemented decreased 0.05), whereas receptor erythrocyte protoprophyrin levels 0.05). Plasma urinary also (%) meal 0.01), 0.01) compared baseline Zn-supplemented women. Our results indicate that use marginal status improves no status. However, modest supplement indices, appears induce cellular deficiency and, possibly, further reduce