Low iron diet and parenteral cadmium exposure in pregnant rats: the effects on trace elements and fetal viability.

摘要: The effects of latent iron deficiency combined with parenteral subchronic or acute cadmium exposure during pregnancy on maternal and fetal tissue distribution cadmium, zinc, viability were evaluated. Timed-pregnant Sprague-Dawley rats fed semisynthetic test diets either high (240 mg kg) low (10 kg), concomitantly exposed to 0, 3 5 (as anhydrous CdCl2) per kilogram body weight. Animals from gestation day 1 through 19 by subcutaneously implanted mini pumps (Subchronic exposure) 15 a single subcutaneous injection (Acute exposure). All killed 19. Blood samples, selected organs fetuses removed prepared for element analyses atomic absorption spectrometry. Low diet caused decreases in weight, liver weights, placental weights concentrations. By exposure, both acute, concentrations increased the increase was dose-related, kidney zinc increased, concentration decreased. Cadmium additionally diet. Acute lower organ mortality, decreased survivors. In conclusion, causes perturbations essential elements compartments. last trimester poses risk especially when