Cadmium in placenta- a valuable biomarker of exposure during pregnancy in biomedical research.

摘要: Rats were exposed to cadmium (Cd) during pregnancy orally (50 ppm Cd in drinking water from gestation day [GD] 1–20) or parenterally (5 mg/kg sc GD 1–19 on 16). Cadmium levels measured blood, placenta, and fetus at the end of exposure. Human studies comprised two cohorts healthy Croatian postpartum women continental versus coastal area; these women, maternal cord blood. rat placenta was 10-fold higher following parenteral oral exposure, with highest value after exposure mid pregnancy. The values than had ≤10% blood metal levels. human noted increased smokers that 10- 20-fold very low (<0.1 ppb). In nonsmokers, different area found due dietary intake. Data showed placenta...