Oral cadmium exposure during rat pregnancy: assessment of transplacental micronutrient transport and steroidogenesis at term.

摘要: Diet is the main source of cadmium (Cd) exposure. Gastrointestinal absorption increases during pregnancy. Cadmium accumulated in placenta may interfere with nutrient transport to foetus. Data on potential Cd act as a steroid disruptor pregnancy are limited. We evaluated effects oral exposure placental function micronutrient transfer foetus and steroidogenesis Wistar rats (regular 4-day cyclers) that mated unexposed males. Pregnant were randomly assigned group exposed orally 50 mg l(-1) (CdCl(2)xH2O dissolved demineralized water), ≈ 7.5 kg(-1) day, 20 days gestation control (supplied water). Non-pregnant treated under same experimental conditions. On day 20, all killed samples taken for element analyses (by electrothermal atomic spectrometry). Progesterone testosterone measured serum placenta-derived immunoenzymometric assay and/or enzyme-linked immunosorbent assay). In rats, increased blood organs, more pregnant whereas zinc liver. Iron decreased maternal organs foetus, kidney placenta. Liver copper was lower higher vs. non-pregnant rats. Steroids did not change. conclusion, rat does affect progesterone at term. Transplacental iron handover disrupted, which put risk maintenance foetal nutrition viability.