Epigenetic regulation of placental glucose transporters mediates maternal cadmium-induced fetal growth restriction.
作者： Peng Xu , Zhongqiang Wu , Yao Xi , Lan Wang
DOI: 10.1016/J.TOX.2016.10.011
关键词:
摘要: Cadmium (Cd) is one of the most toxic environmental pollutants that cause fetal malformation and growth restriction. However, molecular mechanisms underlying maternal Cd toxicity on remain largely unknown. Specifically, role placental nutrient transporters, including glucose transporters (GLUTs), has been poorly characterized in etiology Cd-induced restriction (FGR). In present study, we established a murine model FGR induced by exposure, examined effects GLUTs. Our results showed GLUT3 significantly downregulated Cd-exposed mouse placentas when compared to normal ones. Data from bisulfite PCR demonstrated hypermethylation promoter region GLUT3. methylation levels remained unchanged two major repetitive elements (LINE-1 IAP) placentas. Moreover, DNA methyltransferase (DNMT) 3B DNMT3L were upregulated placentas, there no expression changes DNMT1 DNMT3A. Collectively, our suggest DNMT3B expressions site-specific may be involved through downregulation
sci-hub.se 参考文章(59)
N.P. Illsley, Glucose transporters in the human placenta. Placenta. ,vol. 21, pp. 14- 22 ,(2000) , 10.1053/PLAC.1999.0448
Maja Vihnanek Lazarus, Ankica Sekovanić, Zorana Kljaković-Gašpić, Tatjana Orct, Jasna Jurasović, Josip Kusak, Slaven Reljić, Đuro Huber, Cadmium and lead in grey wolf liver samples: optimisation of a microwave-assisted digestion method. Arhiv Za Higijenu Rada I Toksikologiju. ,vol. 64, pp. 395- 403 ,(2013) , 10.2478/10004-1254-64-2013-2323
Anja Mikolić, Martina Piasek, Antonija Sulimanec Grgec, Veda M. Varnai, Sandra Stasenko, Saša Kralik Oguić, Oral cadmium exposure during rat pregnancy: assessment of transplacental micronutrient transport and steroidogenesis at term. Journal of Applied Toxicology. ,vol. 35, pp. 508- 519 ,(2015) , 10.1002/JAT.3055
MarÃa Teresa Antonio GarcÃa, Elvira Luján Massó González, Natural Antioxidants Protect Against Cadmium‐Induced Damage during Pregnancy and Lactation in Rats' Pups Journal of Food Science. ,vol. 75, ,(2010) , 10.1111/J.1750-3841.2009.01432.X
Michael C. Henson, P. Jorge Chedrese, Endocrine disruption by cadmium, a common environmental toxicant with paradoxical effects on reproduction. Experimental Biology and Medicine. ,vol. 229, pp. 383- 392 ,(2004) , 10.1177/153537020422900506
Yoshimasa Kamei, Osamu Tsutsumi, Akio Yamakawa, Yoshitomo Oka, Yuji Taketani, Junko Imaki, Maternal epidermal growth factor deficiency causes fetal hypoglycemia and intrauterine growth retardation in mice: possible involvement of placental glucose transporter GLUT3 expression. Endocrinology. ,vol. 140, pp. 4236- 4243 ,(1999) , 10.1210/ENDO.140.9.6993
Jovita V. Kavitha, Fredrick J. Rosario, Mark J. Nijland, Thomas J. McDonald, Guoyao Wu, Yoshikatsu Kanai, Theresa L. Powell, Peter W. Nathanielsz, Thomas Jansson, Down-regulation of placental mTOR, insulin/IGF-I signaling, and nutrient transporters in response to maternal nutrient restriction in the baboon The FASEB Journal. ,vol. 28, pp. 1294- 1305 ,(2014) , 10.1096/FJ.13-242271
Heikki Kainulainen, Teppo Järvinen, Pentti Heinonen, Placental glucose transporters in fetal intrauterine growth retardation and macrosomia. Gynecologic and Obstetric Investigation. ,vol. 44, pp. 89- 92 ,(1997) , 10.1159/000291493
Yu Gao, Zhiming He, Zilian Wang, Yanmin Luo, Hongyu Sun, Yi Zhou, Linhuan Huang, Manchao Li, Qun Fang, Shiwen Jiang, Increased Expression and Altered Methylation of HERVWE1 in the Human Placentas of Smaller Fetuses from Monozygotic, Dichorionic, Discordant Twins PLoS ONE. ,vol. 7, pp. e33503- ,(2012) , 10.1371/JOURNAL.PONE.0033503
Anna Winiarska-Mieczan, Cumulative rate and distribution of Cd and Pb in the organs of adult male Wistar rats during oral exposure. Environmental Toxicology and Pharmacology. ,vol. 38, pp. 751- 760 ,(2014) , 10.1016/J.ETAP.2014.08.016