Downregulations of placental fatty acid transporters during cadmium-induced fetal growth restriction.
作者： Peng Xu , Huiqin Guo , Huan Wang , Shao Chin Lee , Ming Liu
DOI: 10.1016/J.TOX.2019.05.013
关键词: Receptor 、 Internal medicine 、 Peroxisome 、 Fatty acid 、 NEFA 、 Peroxisome proliferator-activated receptor 、 Endocrinology 、 Fatty Acid Binding Protein 3 、 Triglyceride 、 Placenta 、 Chemistry
摘要: Cadmium (Cd) is one of the environmental pollutants, which has multiple toxic effects on fetuses and placentas. Placental fatty acid (FA) uptake transport are critical for fetal placental development. We aimed to analyze triglyceride (TG) level, expression patterns several key genes involved in FA transport, molecular mechanisms altered gene expressions placentas response Cd treatment. Our results showed that TG level was significantly decreased Cd-exposed Fatty transporting protein 1 (FATP1), FATP6 binding 3 (FABP3) were down-regulated from mice. The phospho-p38 MAPK increased by treatment, while total p38 remained unchanged. levels peroxisome proliferator-activated receptor-γ (PPAR-γ) hypoxia-inducible factor-1α (HIF-1α) methylation promoter regions FATP1, FABP3 no significant differences between treatment control groups. In addition, circulating non-esterified (NEFA), cholesterol (TC), not maternal serum Therefore, our suggest exposure dose reduce supply, but reduces level. also downregulates FABP3, respectively associated with p38-MAPK, MAPK/PPAR-γ HIF-1α pathways.
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