Disruption of the zinc metabolism in rat fœtal brain after prenatal exposure to cadmium

摘要: This study was carried out to investigate the effects of maternal Cd and/or Zn exposure on some parameters metabolism in fetal brain Wistar rats. Thus, female controls and other exposed by oral route during gestation period (50 mg CdCl2/L) (ZnCl2 60 mg/L) were used. The male fetuses at age 20 days (GD20) sacrificed their brains taken for histological, chemical molecular analysis. depletion observed issued from mothers Cd. Histological analysis showed that induces pyknosis cortical region CA1 hippocampus compared controls. Under exposure, we noted an overexpression genes coding membrane transporter involved intracellular incorporation (ZIP6) associated with inhibition encoding transporters output into extracellular medium (ZnT1 ZnT3). A decrease expression gene neuro-trophic factor (BDNF) metal regulatory transcription 1 (MTF1), homeostasis Zn, also group. Interestingly, supply provided a total or partial restauration changes induced exposure. contents as well modification profile transporters, suggest toxicity level are mediated, part, impairment metabolism.