Cold atmospheric plasma and iron oxide-based magnetic nanoparticles for synergetic lung cancer therapy.

摘要: Cold atmospheric plasma (CAP) is an emerging biomedical technique that shows great potential for cancer treatment. On the other hand, magnetic nanoparticles open up a wide field of possible applications in medicine. Here we seek to develop novel dual therapeutic method by integrating promising CAP and iron oxide-based (MNPs), evaluate its underlying mechanism targeted lung For this purpose, synergistic effects MNPs on cellular bioactivity, epidermal growth factor receptor (EGFR) expression, EGFR downstream signaling pathways were investigated. Results showed effectiveness strongly killed activity against cells, significantly inhibited cell proliferation via reduction viability induction apoptosis. Importantly, combining with induced downregulation while cells depressing pERK pAKT. Translation these findings vivo setting demonstrates effective at preventing xenograft tumors. Thus, integration provides tool development new treatment strategy.