Actin and Diseases of the Nervous System
作者： Barbara W. Bernstein , Michael T. Maloney , James R. Bamburg
DOI: 10.1007/978-1-4419-7368-9_11
关键词: Neuroscience 、 Nervous system 、 Cofilin 、 Neurodegeneration 、 Cell biology 、 Biology 、 Actin cytoskeleton 、 Cell 、 Actin depolymerizing factor 、 Dendritic spine 、 Actin
摘要: Abnormal regulation of the actin cytoskeleton results in several pathological conditions affecting primarily nervous system. Those genetic origin arise during development, but others manifest later life. Actin is also affected profoundly by environmental factors that can have sustained consequences for follow from fact essential a multitude cell biological functions ranging neuronal migration cortical development and dendritic spine formation to NMDA receptor activity learning alcoholism. Improper actin, causing aggregation, contribute neurodegeneration amyloidopathies, such as Down’s syndrome Alzheimer’s disease. Much progress has been made understanding molecular basis these diseases.
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