Diazepam in the prevention of seizures and death in cocaine-intoxicated rats

摘要: Rats were exposed to high-dose intraperitoneal cocaine. Pretreatment with diazepam was found be highly effective in reducing observed seizures from 90% 0% and the incidence of death 85% 10%. Furthermore, treatment after cocaine exposure also decreasing deaths, 80% 21%, even when given onset seizures. Although pretreatment shown prevent clinically overt seizures, cortical EEGs these rats demonstrated a continuum convulsantlike electrical activity Our study points protective effects before or exposure. Together, data suggest that has significant efficacy against intoxication though it does not totally suppress cocaineinduced EEG seizure activity.