Congenital anomalies in children with cerebral palsy: a population-based record linkage study

摘要: Aim  Our aim was to determine the proportion of children with cerebral palsy (CP) who have a congenital anomaly (CA) in three regions (Isere Region, French Alps; Funen County, Denmark; Northern England) where population-based CP and CA registries exist, classify according subtype. Method  Data for born between 1991 1999 were linked using electronic matching cases. All potential matches checked manually by each centre verified as true matches. Results  A total 1104 during study period (663 males, 441 females). Of these, 166 (15%; 95% Confidence Interval [CI] 13.0–17.3) had CA: 8.8% anomaly, 4.8% non-cerebral 1.4% non-cerebral-related syndrome or chromosomal/genetic anomaly. Interpretation  The prevalence highest ataxic (41.7%) lowest those dyskinetic (2.1%). Cerebral anomalies found 8.4% 7% bilateral unilateral spastic respectively. most frequent primary microcephaly (26.5%) hydrocephalus (17.3%). common recorded cardiac (12.6% CA), urinary (5.4%), musculoskeletal (5.4%). higher among at term (13%) than preterm (3.8%). Associated sensorineural intellectual impairments occurred more often anomalies. We concluded that population general live births.