Nrf2 Activates Augmenter of Liver Regeneration (ALR) via Antioxidant Response Element and Links Oxidative Stress to Liver Regeneration

作者: Rania Dayoub , Arndt Vogel , Jutta Schuett , Madeleine Lupke , Susannah M. Spieker

DOI: 10.2119/MOLMED.2013.00027

关键词: Oxidative stressIn vitroMolecular biologyCell cultureAntioxidant Response ElementsBiochemistryLiver regenerationRegeneration (biology)Hepatitis C virusMolecular medicineBiology

摘要: … To identify these potential ARE motifs in the ALR promoter, we examined the human ALR (gene ID 2671) genomic locus and revealed one putative ARE sequence in the human ALR …

参考文章(49)
Elisavet Gatzidou, Gregory Kouraklis, Stamatios Theocharis, Insights on augmenter of liver regeneration cloning and function World Journal of Gastroenterology. ,vol. 12, pp. 4951- 4958 ,(2006) , 10.3748/WJG.V12.I31.4951
Xin Wu, Lijian Hui, Zheguang Han, Yanping Wang, Ying Jin, Jialei Gong, Yuan Ji, Shaohui Wang, Gengxi Hu, Liang Xu, Expression profiling suggested a regulatory role of liver-enriched transcription factors in human hepatocellular carcinoma Cancer Research. ,vol. 61, pp. 3176- 3181 ,(2001)
Yanlin Zhao, Fei Tang, Jingwei Cheng, Li Li, Guichun Xing, Yunping Zhu, Lingqiang Zhang, Handong Wei, Fuchu He, An initiator and its flanking elements function as a core promoter driving transcription of the Hepatopoietin gene. FEBS Letters. ,vol. 540, pp. 58- 64 ,(2003) , 10.1016/S0014-5793(03)00158-3
Makoto Kobayashi, Masayuki Yamamoto, Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation. Antioxidants & Redox Signaling. ,vol. 7, pp. 385- 394 ,(2005) , 10.1089/ARS.2005.7.385
Yasutake Katoh, Tatsuya Oyake, Norio Hayashi, Kimihiko Satoh, Ichiro Hatayama, Masayuki Yamamoto, Yo-ichi Nabeshima, Ken Itoh, Tomoki Chiba, Satoru Takahashi, Tetsuro Ishii, Kazuhiko Igarashi, AN NRF2/SMALL MAF HETERODIMER MEDIATES THE INDUCTION OF PHASE II DETOXIFYING ENZYME GENES THROUGH ANTIOXIDANT RESPONSE ELEMENTS Biochemical and Biophysical Research Communications. ,vol. 236, pp. 313- 322 ,(1997) , 10.1006/BBRC.1997.6943
Maren Ilowski, Christine Putz, Thomas S. Weiss, Stephan Brand, Karl-Walter Jauch, Jan G. Hengstler, Wolfgang Erwin Thasler, Augmenter of liver regeneration causes different kinetics of ERK1/2 and Akt/PKB phosphorylation than EGF and induces hepatocyte proliferation in an EGF receptor independent and liver specific manner. Biochemical and Biophysical Research Communications. ,vol. 394, pp. 915- 920 ,(2010) , 10.1016/J.BBRC.2010.03.074
Takaji Wakita, Thomas Pietschmann, Takanobu Kato, Tomoko Date, Michiko Miyamoto, Zijiang Zhao, Krishna Murthy, Anja Habermann, Hans-Georg Kräusslich, Masashi Mizokami, Ralf Bartenschlager, T Jake Liang, Production of infectious hepatitis C virus in tissue culture from a cloned viral genome Nature Medicine. ,vol. 11, pp. 791- 796 ,(2005) , 10.1038/NM1268
Jong‐Min Lee, Jiang Li, Delinda A. Johnson, Thor D. Stein, Andrew D. Kraft, Marcus J. Calkins, Rebekah J. Jakel, Jeffrey A. Johnson, Nrf2, a multi-organ protector? The FASEB Journal. ,vol. 19, pp. 1061- 1066 ,(2005) , 10.1096/FJ.04-2591HYP
Antonio Francavilla, Michio Hagiya, Kendrick A. Porter, Lorenzo Polimeno, Izumi Ihara, Thomas E. Starzl, Augmenter of liver regeneration: Its place in the universe of hepatic growth factors Hepatology. ,vol. 20, pp. 747- 757 ,(1994) , 10.1002/HEP.1840200328