REGRESSION ANALYSIS OF CHANGES IN BLOOD PRESSURE WITH ORAL CONTRACEPTIVE USE

作者: NANCY R. COOK , PAUL A. SCHERR , DENNIS A. EVANS , LARRY W. LAUGHLIN , WILLIAM G. CHAPMAN

DOI: 10.1093/OXFORDJOURNALS.AJE.A114030

关键词: Internal medicineContraceptive useBlood pressureMedicineRegression analysisCardiologyLinear regressionMyocardial infarctionEndocrinologySystoleStrokeOral administration

摘要: Hypertension Detection and Follow-up Program data on 927 women who were surveyed 3 times in 1973-78 premenopausal not pregnant taking antihypertensive medication analyzed to determine the relationship between oral contraceptive (OC) use blood pressure. Mean systolic pressures consistently higher OC users that nonusers with an average difference of 2.3 mmHg. The for diastolic pressure was 0.6 When estimated effects adjusted current age weight through linear regression analysis increase 3.5 mm noted adapted course study relative never users. effect stopping a 2.8 decrease combined starting only 0.56 pressure; however 2.1 continuing 1.3 mm. Regression level smoking habits included model indicated 3.9 among negligible increases Further drops 0.3 every year since last whereas duration but time is significant predictor Comparison by estrogen progestin dose feasible there no apparent type overall upon consistent results from other studies. Although are they sufficient magnitude fully account increased risk stroke myocardial infarction found

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