Chemopreventive effects of nobiletin and its colonic metabolites on colon carcinogenesis
作者： Xian Wu , Mingyue Song , Minqi Wang , Jinkai Zheng , Zili Gao
关键词: Pathology 、 Programmed cell death 、 Cell 、 Cell growth 、 Nobiletin 、 Colitis 、 Colorectal cancer 、 Azoxymethane 、 Medicine 、 Cancer research 、 Apoptosis
摘要: SCOPE: Nobiletin (NBT) is a major citrus flavonoid with various health benefits. Herein, we investigated the colon cancer chemopreventive effects of NBT and its colonic metabolites in colitis‐associated carcinogenesis mouse model as well human cell models. METHODS AND RESULTS: In azoxymethane/dextran sulfate sodium treated mice, oral administration effectively decreased both incidence multiplicity tumors. showed significant antiproliferative, proapoptotic, anti‐inflammatory colon. HPLC analysis revealed that resulted high levels metabolites, i.e. 3′‐demethylnobiletin (M1), 4′‐demethylnobiletin (M2), 3′,4′‐didemethylnobiletin (M3) mucosa. contrast, level was about 20‐fold lower than total three metabolites. Cell culture studies demonstrated significantly inhibited growth cells, caused cell‐cycle arrest, induced apoptosis, profoundly modulated signaling proteins related proliferation death. All these were much stronger those produced by alone. CONCLUSION: Our results this effect strongly associated
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