Variations in the bitterness perception-related genes TAS2R38 and CA6 modify the risk for colorectal cancer in Koreans

摘要: // Jeong-Hwa Choi 1 , Jeonghee Lee Jae Hwan Oh 2 Hee Jin Chang Dae Kyung Sohn Aesun Shin 3 Jeongseon Kim Molecular Epidemiology Branch, Division of Cancer and Prevention, National Center, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10408, Korea Center for Colorectal Cancer, Hospital, Department Preventive Medicine, Seoul University College Jongno-gu, Seoul, 03080, Correspondence to: Kim, email: jskim@ncc.re.kr Shin, shinaesun@snu.ac.kr Keywords: bitterness perception, CA6, colorectal cancer, dietary intake, TAS2R38 Received: November 08, 2016      Accepted: February 07, 2017      Published: 19, 2017 ABSTRACT Bitterness perception is known to be an important factor in individuals’ behaviors also associated with the sensing nutritious/noxious molecules subsequent metabolic responses multiple organs. Therefore, genetic variation may diet-related diseases, including cancer (CRC). We investigated influence variations bitterness-sensing genes taste receptor type member 38 ( ) carbonic anhydrase 6 CA6 on consumption food, tobacco alcohol risk CRC Koreans. The study population consisted 681 cases 1361 controls, their intake vegetables, fruits, fiber, fat-food sweets was analyzed. genotypes A49P, V262A I296V rs2274333 A/G were assessed using MassArray technique. Our findings suggested that diplotype, combined genotype had a negligible intake. TAS2R38-CA6 AVI/AVI-AA higher than other only. However, significant CRC. AVI/AVI diplotype G allele reduced Moreover, when subjects analyzed, possessing both variant diplotype/variant (AVI/AVI+G*) greater reduction (adjusted OR = 0.49; 95%CI: 0.34–0.74). In summary, did not examined food those variants decisive modifying susceptibility.