Prognostic value of heart rate variability in patients with renal failure on hemodialysis

摘要: Abstract Background In patients with renal failure on hemodialysis cardiovascular disease is a major cause of death. It has been reported that diminished heart rate variability (HRV) relates to the unfavorable prognosis in post-infarction and/or patients. However, prognostic value HRV not fully established. Methods and results Time- frequency-domain analysis 24-hour ambulatory electrocardiography recording was assessed prospectively 383 chronic (220 men 163 women, mean age 57±13 years, ejection fraction 65±12%). During 2110±903 days follow up, 146 died (31 congestive failure, 13 fatal myocardial infarction, sudden deaths, 26 stroke, 63 non-cardiovascular deaths). A Cox univariate identified following factors as predictors both all-cause death: age, gender, fraction, presence diabetes, parameters calculated time- frequency-domain. multivariate analysis, low standard deviation all normal RR intervals (SDNN) strongly associated death (hazard ratios [95% confidence intervals] 0.988 [0.982–0.994] 0.984 [0.974–0.993], respectively). From Kaplan–Meier survival curves, incidence much greater SDNN ( P Conclusions Decreased an independent predictor mortality