Uremic autonomic neuropathy: recovery following bicarbonate hemodialysis.

摘要: Autonomic function was followed in 8 chronic uremic patients on periodic hemodialysis over a period of almost eight years. The cardiovascular autonomic testing included R-R interval variation test, deep breathing, Valsalva manoeuvre, heart rate and blood pressure responses to standing, sustained handgrip. were investigated entry into the study after 18, 56, 92 months. Six months at time 56 months, they switched from acetate bicarbonate dialysis. response breathing test significantly reduced 18 versus baseline (P = 0.014), but increased 0.042). A significant decrease found systolic standing between 0.014) handgrip 0.014). Multivariate analysis tests by pattern recognition method (Bayesian analysis) showed that, study, two out had damage. At 6/8 dysfunction. last investigation, 30 onset dialysis, all reversal Age duration dialysis did not affect function. present is first demonstration that neuropathy can recover long-term Since hypoxemia cause polyneuropathy, we postulate that: 1) may have role pathogenesis particularly dysfunction; 2) greater hemodynamic stability with less lead recovery