The long noncoding RNA colon cancer-associated transcript-1/miR-490 axis regulates gastric cancer cell migration by targeting hnRNPA1
作者： Baoguo Zhou , Yuli Wang , Jinpeng Jiang , Hongpeng Jiang , Jianwei Song
DOI: 10.1002/IUB.1474
关键词: Gene silencing 、 Molecular biology 、 microRNA 、 Cancer research 、 Cancer 、 Gene expression 、 Messenger RNA 、 Cell growth 、 Biology 、 Cell migration 、 RNA interference
摘要: Colon cancer-associated transcript-1 (CCAT1) is a highly conserved long noncoding RNA that deregulated in several cancers. However, its role gastric carcinoma and post-transcriptional regulation remain poorly understood. In this study, we provide the first evidence CCAT1 regulates miR-490 cancer (GC) cells. Interestingly, can also repress expression. expression was significantly upregulated, downregulated GC. The negative correlation between observed GC tissues. Importantly, contains putative miR-490-binding site, deletion of binding site abolishes their responsiveness. Post-transcriptional silencing by suppressed cell migration. Furthermore, directly bound to hnRNPA1 mRNA 3'-UTR translation. Inhibition rescued siRNA-mediated suppression upregulated specimens, there positive hnRNAP1 level level. Taken together, show for time CCAT1/miR-490/hnRNPA1 axis promotes migration, it may have possible diagnostic therapeutic potential
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