Loss of tumor suppressor gene expression in high-grade but not low-grade non-Hodgkin's lymphomas.

摘要: The products of the MTSI/CDKN2 and retinoblastoma (RB) tumor suppressor genes, p16 pRB, act as agonists in controlling late G 1 cell cycle checkpoint. Inactivation either gene occurs a wide range human malignant neoplasms. Data on expression both genes same set lymphoid neoplasms are scarce. We studied p16/pRB pathway low-grade high-grade non-Hodgkin's lymphomas, using immunohistochemical techniques. Paraffin sections 9 reactive lymph nodes 43 60 lymphomas were reacted with antibodies against pRB p16. All benign showed normal pattern RB MTS1/CDKN2 expression. Of 101 evaluable only single displayed loss reactivity. Loss was identified 14 55 but not any lesions. 3 RB- p16-negative cases diffuse large for an abnormality rate 55% this category. While function rare event lymphomagenesis, absent some 25% lymphomas; primary target inactivation.