Role of the INK4a locus in tumor suppression and cell mortality

作者: Manuel Serrano , Han-Woong Lee , Lynda Chin , Carlos Cordon-Cardo , David Beach

DOI: 10.1016/S0092-8674(00)81079-X

关键词:

摘要: The cell cycle inhibitor p16INK4a is inactivated in many human tumors and in families with hereditary melanoma and pancreatic cancer. Tumor-associated alterations in the INK4a …

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