Primary and Secondary Events in Oncogene-Driven Tumor Development
作者： Michaela Herzig , Gerhard Christofori
DOI: 10.1007/978-1-59259-313-2_13
关键词: Function (biology) 、 Cancer research 、 Oncogene 、 Gene 、 Loss function 、 Carcinogenesis 、 Biology 、 Genetically modified mouse 、 Tumor progression 、 Adenomatous polyposis coli
摘要: Molecular analysis of multistage carcinogenesis in patients is mainly hampered by the inavailability biopsies from early tumor stages. In contrast, mouse models development offer means to reproducibly isolate different stages progression, which then are amenable pathological, genetic, and biochemical analyses. Moreover, cell lines derived useful tools experimentally addressing many cancer-related questions. Finally, genetic modulation gene function overexpression transgenic mice (gain function) or ablation knock-out (loss provide opportunity determine whether observed changes cause consequence development. Hence, murine have been instrumental identifying genes unraveling their causal role carcinogenesis.
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