E mu-bcl-2 transgene facilitates spontaneous transformation of early pre-B and immunoglobulin-secreting cells but not T cells.

摘要: To assess the lymphoid tumorigenic potential of bcl-2, mice five independent strains expressing a bcl-2 transgene in B and/or T cells were monitored for disease up to 12 months age. Lymphoma prevalence was minimal lineage but significant, although low (3-15%), lineage. The principal types tumors plasmacytomas secreting immunoglobulin and novel lymphomas that expressed markers such as Sca-1, CD4, Thy-1, CD34 CD45(B220), consistent with an origin very early B-lymphoid development. Rearrangement c-myc gene common plasmacytomas, implying synergistic role myc their etiology, not detected lymphomas.