N-myc transgene promotes B lymphoid proliferation, elicits lymphomas and reveals cross-regulation with c-myc.

摘要: To assess the impact of constitutive N-myc expression on lymphocytes, we generated lines transgenic mice bearing murine oncogene coupled to immunoglobulin heavy chain enhancer (E mu). As in carrying an analogous c-myc construct, E mu-N-myc exhibit a limited overgrowth cycling pre-B cells and eventually succumb clonal B lymphoid tumours. The endogenous alleles are silent both mu-myc lymphomas, suggesting that these genes subject auto- cross-regulation. regulatory interaction similar biological effects imply two perform interchangeable functions promotion cell proliferation.