Human Neuroblastoma: Paradigm for a Tumor with Oncogene Amplification and Loss of a Putative Tumor Suppressor Gene
作者： M. Schwab
DOI: 10.1007/978-3-642-76829-3_36
关键词: Chromosome 、 Cancer research 、 Neuroblastoma cell 、 Biology 、 DNA 、 Oncogene amplification 、 Neuroblastoma 、 Tumor suppressor gene 、 Cyclin-dependent kinase 8 、 Oncogene
摘要: Human neuroblastoma cells often carry nonrandom chromosomal abnormalities signaling genetic alterations. Quite frequent are “double minutes” (DMs) and homogeneously staining regions (HSRs), both cytogenetic manifestations of amplified DNA, chromosome 1 p deletions indicating loss information. With the identification N-myc demonstration a consensus deletion spanning p36.1–2 region it now appears likely that amplification cellular oncogene tumor suppressor gene play important roles in (Fig.1).
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