Bone growth resumption following in vivo static and dynamic compression removals on rats.
作者： Anne-Laure Ménard , Guy Grimard , Irène Londono , Francis Beaudry , Pascal Vachon
DOI: 10.1016/J.BONE.2015.09.013
关键词: Bone development 、 Weight-bearing 、 Surgery 、 Dynamic range compression 、 Anesthesia 、 Rats sprague dawley 、 Chemistry 、 Bone density 、 Static loading 、 Bone growth 、 In vivo
摘要: Mechanical loadings influence bone growth and are used in pediatric treatments of musculoskeletal deformities. This vivo study aimed at evaluating the effects static dynamic compression application subsequent removal on growth, mineralization neuropathic pain markers growing rats. Forty-eight immature rats (28 days old) were assigned two groups (2- 4 weeks experiment duration) four subgroups: control, sham, static, dynamic. Controls had no surgery. A micro-loading device was implanted 6th 8th caudal vertebrae shams without loading, loading 0.2 MPa or ± 30% 0.1 Hz. In 2-week subgroups, maintained for 15 prior to euthanasia, while 4- week removed 10 additional days. Growth rates, histomorphometric parameters intensity quantified compared. At 2 weeks, rates plate heights loaded (static/dynamic)were significantly lower than (p b 0.01).However, both similar shams. alizarin red higher dynamics compared 0.05) controls 0.01). Both compressions enable resumption after removal, preserving integrity. However, enhanced only. Dynamic showed promising results fusionless treatment approaches
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