Purine and 3-deazapurine analogues as choline kinase inhibitors
作者： Federico Riccardi Sirtori , Marcella Nesi , Francesca Quartieri , Paola Gnocchi , Elena Casale
DOI:
关键词: Choline kinase 、 Biochemistry 、 Purine 、 Cancer 、 Choline metabolism 、 Chemistry 、 Cell
摘要: There are provided substituted purine and 3-deazapurine analogues, which modulate the activity of Choline Kinase (ChoK). The compounds this invention therefore useful in treating diseases caused by an altered choline metabolism, such as cancer, cell proliferative disorders, infectious different origin, immune-related disorders neurodegenerative disorders. present also provides methods for preparing these compounds, pharmaceutical compositions comprising utilizing compounds.
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