Paroxetine-Induced Hyponatremia in Older Adults

摘要: Background Older depressed patients are at high risk for development of hyponatremia after initiation the selective serotonin reuptake inhibitor paroxetine, despite clinical monitoring and preventive management. The purposes this study were to determine incidence etiology paroxetine-induced in older identify patient characteristics that may account variability susceptibility adverse event. Methods This prospective, longitudinal was conducted a university-based ambulatory psychiatric research clinic from August 1999 through September 2001. Patients included 75 men women aged 63 90 years (mean ± SD age, 75.3 6.0 years) who received diagnosis current Diagnostic Statistical Manual Mental Disorders, Fourth Edition, major depressive episode prescribed paroxetine. We monitored plasma sodium levels before initiating paroxetine therapy 1, 2, 4, 6, 12 weeks treatment. In subset individuals, we measured antidiuretic hormone, glucose, serum urea nitrogen, creatinine. Hyponatremia defined as level less than 135 mEq/L therapy. Results developed 9 (12%) Mean time 9.3 4.7 days (median, days; range, 1-14 n = 8). multivariate regression, lower body mass index baseline ( Conclusions is an underrecognized potentially serious complication treatment patients. Our results provide foundation understanding factors associated with hyponatremia.