SSRIs AND THE SYNDROME OF INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION

作者: CAROLE NOELLE ROTTMANN

DOI: 10.1097/00000446-200701000-00022

关键词: HomeostasisSerotonin reuptakeEndocrinologyAsymptomaticAntidiureticHormoneHyponatremiaAdverse effectSyndrome of inappropriate antidiuretic hormone secretionInternal medicineMedicineGeneral NursingGeneral Medicine

摘要: Selective serotonin reuptake inhibitors, which include some of the mostly widely prescribed drugs in United States, produce fewer adverse effects than other types antidepressants. But their use can be associated with disruption action antidiuretic hormone body, wreaks havoc homeostasis. This may lead to syndrome inappropriate secretion (SIADH), is characterized by hyponatremia, a potentially fatal condition that typically asymptomatic until it becomes severe. SIADH more likely populations, including people who are elderly or take diuretics. Serum sodium levels should monitored closely those at higher risk.

参考文章(9)
Michelle Lin, Stephen J. Liu, Ingrid T. Lim, Disorders of water imbalance. Emergency Medicine Clinics of North America. ,vol. 23, pp. 749- 770 ,(2005) , 10.1016/J.EMC.2005.03.001
R. J. Goldberg, Selective Serotonin Reuptake Inhibitors: Infrequent Medical Adverse Effects Archives of Family Medicine. ,vol. 7, pp. 78- 84 ,(1998) , 10.1001/ARCHFAMI.7.1.78
Christopher SD Almond, Andrew Y Shin, Elizabeth B Fortescue, Rebekah C Mannix, David Wypij, Bryce A Binstadt, Christine N Duncan, David P Olson, Ann E Salerno, Jane W Newburger, David S Greenes, None, Hyponatremia among runners in the Boston Marathon. The New England Journal of Medicine. ,vol. 352, pp. 1550- 1556 ,(2005) , 10.1056/NEJMOA043901
Rohan Wee, Wen Kwang Lim, Selective serotonin re-uptake inhibitors (SSRIs) and hyponatraemia in the elderly. International Journal of Geriatric Psychiatry. ,vol. 19, pp. 590- 591 ,(2004) , 10.1002/GPS.1096
Tanya J. Fabian, Janet A. Amico, Patricia D. Kroboth, Benoit H. Mulsant, Sharon E. Corey, Amy E. Begley, Salem G. Bensasi, Elizabeth Weber, Mary Amanda Dew, Charles F. Reynolds III, Bruce G. Pollock, Paroxetine-Induced Hyponatremia in Older Adults Archives of Internal Medicine. ,vol. 164, pp. 327- 332 ,(2004) , 10.1001/ARCHINTE.164.3.327
Susan Jacob, Sarah A Spinier, Hyponatremia Associated with Selective Serotonin-Reuptake Inhibitors in Older Adults Annals of Pharmacotherapy. ,vol. 40, pp. 1618- 1622 ,(2006) , 10.1345/APH.1G293