Total Synthesis of the Lindenane-Associated Terpenoids

摘要: Abstract Lindenane-type sesquiterpenoids are characteristic metabolites in the genus Chloranthus . These natural sesquiterpenoid monomers and associated dimers sesterterpenoids intriguing because of their complex novel molecular architecture significant bioactivities. Herein, establishment synthetic routes toward lindenane-associated this family is described detail. The process simplifying a lengthy synthesis to concise one showcased through illumination new ideas development methodology. A number total syntheses target molecules were conceived realized, during which unexpected experimental discoveries made, then served as inspiration for useful Importantly, practice showed that we should be inspired but not limited by biogenetic hypotheses biohypothesis could modified improved based on understanding key reactions explored chemical synthesis.