Induction of Interferons (IFNs) and Tumor Necrosis Factor (TNF) in Mice by a Novel Glycolipid Trehalose 2,3,6′-Trimycolate fromRhodococcus aurantiacus (Gordona aurantiaca)
作者： Takako Fujita , Nobuko Sugimoto , Fusa Yokoi , Yoshikazu Ohtsubo , Masatoshi Ikutoh
DOI: 10.1111/J.1348-0421.1990.TB03169.X
关键词: Spleen 、 Trehalose 、 Cytokine 、 Biology 、 Microbiology 、 Lipopolysaccharide 、 Interferon 、 Ratón 、 Glycolipid 、 Tumor necrosis factor alpha 、 Immunology 、 Virology
摘要: The immunomodifying activity of a novel mycoloyl glycolipid, trehalose 2,3,6'-trimycolate (GaGM), from unique psychrophilic acid-fast bacterium, Rhodococcus aurantiacus, was examined. ICR mice were primed intravenously (i.v.) or intraperitoneally (i.p.) with liposomes containing GaGM (300 micrograms/mouse), and administered LPS dissolved in saline (25 micrograms/mouse, i.v.) 2 weeks later. Two hours after injection LPS, interferons (IFNs) tumor necrosis factor (TNF) induced significantly sera. increase activities IFNs TNF approximately paralleled granuloma formation spleen GaGM. However, not either but elicited those by Both lower mono- dimycolate R. aurantiacus (GaTMM, GaTDM) TDM Nocardia rubra than GaGM-primed mice. Time course study showed that the maximum each interferon (alpha, beta, gamma) observed at different stages administration; IFN-alpha, IFN-beta, IFN-gamma appeared 3, 2, 6 most abundantly administration, respectively.
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