Genetic Polymorphisms in Cell Cycle Regulatory Genes MDM2 and TP53 Are Associated With Susceptibility to Lung Cancer

作者: Xuemei Zhang , Xiaoping Miao , Yongli Guo , Wen Tan , Yifeng Zhou

DOI: 10.1002/HUMU.20277

关键词: Odds ratioCancer researchBiologyGenetic predispositionCarcinogenesisGenotypePromoterRestriction fragment length polymorphismLung cancerGenetic variation

摘要: … of lung cancer were estimated by logistic regression. We observed an increased lung cancer risk associated with the MDM2 GG (… MDM2 gene amplification: a new independent factor of …

参考文章(35)
Y. Haupt, Y. Barak, M. Oren, Cell type-specific inhibition of p53-mediated apoptosis by mdm2. The EMBO Journal. ,vol. 15, pp. 1596- 1606 ,(1996) , 10.1002/J.1460-2075.1996.TB00504.X
Alan Storey, Miranda Thomas, Ann Kalita, Catherine Harwood, Daniela Gardiol, Fiamma Mantovani, Judith Breuer, Irene M. Leigh, Greg Matlashewski, Lawrence Banks, Role of a p53 polymorphism in the development of human papillomavirus-associated cancer. Nature. ,vol. 393, pp. 229- 234 ,(1998) , 10.1038/30400
A Matakidou, T Eisen, RS Houlston, TP53 polymorphisms and lung cancer risk: a systematic review and meta‐analysis Mutagenesis. ,vol. 18, pp. 377- 385 ,(2003) , 10.1093/MUTAGE/GEG008
Dorota Dworakowska, Ewa Jassem, Jacek Jassem, Brigitte Peters, Rafał Dziadziuszko, Maciej Żylicz, Joanna Jakóbkiewicz-Banecka, Grażyna Kobierska-Gulida, Amelia Szymanowska, Jan Skokowski, Albert Roessner, Regine Schneider-Stock, MDM2 gene amplification: a new independent factor of adverse prognosis in non-small cell lung cancer (NSCLC) Lung Cancer. ,vol. 43, pp. 285- 295 ,(2004) , 10.1016/J.LUNGCAN.2003.09.010
Béatrice Eymin, Sylvie Gazzeri, Christian Brambilla, Elisabeth Brambilla, Mdm2 overexpression and p14(ARF) inactivation are two mutually exclusive events in primary human lung tumors. Oncogene. ,vol. 21, pp. 2750- 2761 ,(2002) , 10.1038/SJ.ONC.1205359
Arnold J Levine, p53, the Cellular Gatekeeper for Growth and Division Cell. ,vol. 88, pp. 323- 331 ,(1997) , 10.1016/S0092-8674(00)81871-1
David Malkin, Frederick P Li, Louise C Strong, Joseph F Fraumeni Jr, Camille E Nelson, David H Kim, Jayne Kassel, Magdalena A Gryka, Farideh Z Bischoff, Michael A Tainsky, Stephen H Friend, Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms Science. ,vol. 250, pp. 1233- 1238 ,(1990) , 10.1126/SCIENCE.1978757
S. Ara, P.S.Y. Lee, M.F. Hansen, H. Saya, Codon 72 polymorphism of the TP53 gene. Nucleic Acids Research. ,vol. 18, pp. 4961- 4961 ,(1990) , 10.1093/NAR/18.16.4961
Patrick Chène, Inhibiting the p53–MDM2 interaction: an important target for cancer therapy Nature Reviews Cancer. ,vol. 3, pp. 102- 109 ,(2003) , 10.1038/NRC991