Substance P is not involved in vascular nociception in humans
作者： H Holthusen , D Kindgen-Milles , Z.P Ding
DOI: 10.1016/S0143-4179(97)90038-X
关键词: Vascular pain 、 Anesthesia 、 Evoked pain 、 Blood vessel 、 Neuropeptide 、 Nociception 、 Substance P 、 Circulatory system 、 Medicine
摘要: Blood vessels are similar to skin invested with substance P-containing nerves and the binding sites for P, which has been shown be involved in nociception from skin. No attempts have made so far see whether P is also vascular nociception. We therefore tested its algesic properties human veins because their innervation exclusively subserves Substance never evoked pain at concentrations of 10(-8)-10(-4) M but did a concentration-related fashion Therefore, not generation acute pain.
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