Toxic stress prioritizes and imbalances stem cell differentiation: implications for new biomarkers and in vitro toxicology tests
作者： Daniel A. Rappolee , Yufen Xie , Jill A. Slater , Sichang Zhou , Elizabeth E. Puscheck
DOI: 10.3109/19396368.2011.647381
关键词: Anabolism 、 Biotechnology 、 Cellular differentiation 、 Catabolism 、 Biology 、 Apoptosis 、 Stem cell 、 Cell biology 、 Conceptus 、 In vivo 、 In vitro toxicology
摘要: This hypothesis and review introduces rules of stem cell stress responses that provide biomarkers alternative testing replaces or reduces gestational tests using whole animals. These for the cultured cells validate organismal strategy response show it emulates what must happen if conceptus implants during a to in vivo. Specifically there is profound threshold dose where accumulation significantly reduced. Below this enzymes manage by converting anabolic catabolic processes suppressing apoptosis, without affecting differentiation. However above survival converts an switch new substrates mediate loss potency factors, gain early essential differentiated lineages, suppression later lineages. Stressed ‘compens...
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